The Real Life Partners Of The Grey’s Anatomy Cast

The Real Life Partners Of The Grey’s Anatomy Cast

Grey’s Anatomy is a much loved American medical drama series that airs on ABC.  The show revolves around the personal lives and career of the lead character, Meredith Grey, and other medical staffs. 

It first graced our TV screens on March 27, 2005. At first, it was seen as just another American medical drama series, one of the hundreds that had been on the air over the years, but as the series continued, it was clear that Grey’s Anatomy was anything but ordinary. The series started off by focusing on the challenging lives of surgical interns, and as the series progressed we got to watch them blossom into residents, attending physicians and even become heads of their own surgical department.

Of course, no medical drama would be complete without drama. And that is exactly what Grey’s Anatomy is known for, DRAMA! Whether it is relationship troubles, a difficult diagnosis, getting too close to patients, tragic events (how could we forget the infamous shooting and plane crash episodes) or so on- Grey’s Anatomy definitely knows how to make some emotional on-screen moments.

With 14 seasons, it is the 10th-longest-running scripted primetime TV series in the US and  it has a HUGE fan base.

If you’re a fan, you can probably relate to the fact that we’re often just as concerned about the relationships of the actors in real life as well as on screen! 

Here are the real-life partners of the incredible cast of Grey’s Anatomy…

Ellen Pompeo & Chris Ivery

Ellen Pompeo started her acting career in the late ’90s, where she first appeared in a small role in the film Coming Soon.


Only months before she made her debut as Meredith Grey, she appeared in an episode of Friends where she played Ross and Chandler’s old college crush, Missy Goldberg. However, there’s no doubt that Pompeo got her big break when she was cast as Meredith Grey.

Meredith has always been considered as one of the best doctors in the hospital and even won a Harper Avery Award for her accomplishments.

Pompeo married music producer Chris Ivery in 2007!

They now have three children together. Aw!

Patrick Dempsey & Jillian Fink

Patrick Dempsey played Derek Shepherd, aka Dr. McDreamy, and was Grey Sloan Memorial Hospital’s most charming neurosurgeon. Him and Meredith Grey fell deeply in love early on in the series while she was still a new intern.

Although the couple had their ups and downs, including Derek failing to tell Meredith that he was married to Addison at the time, they eventually got married and have three children together.

In real life, Patrick Dempsey reached success as an actor early on in films like Can’t Buy me Love, Loverboy and Sweet Home Alabama.

When he left Grey’s Anatomy in 2015, it came as a shocker to many fans. According to the Grey’s star, it “had been long enough” and he was ready to move on, which he did pretty quickly by appearing in Bridget Jones’s Baby the following year.

He married Jillian Fink in 1999 and the beautiful couple have three children together. Adorable!

Justin Chambers & Keisha Chambers

Justin Chambers played Alex Karev in the show and is one of Grey’s original cast and longest-lasting characters.

Along with Meredith, Miranda and Richard, Alex has been saving lives since the very first episode, and is still appearing in the newest season.

He tends to have a bad attitude, although he also has a sweet, caring and incredibly compassionate side that he shows to the ones he loves.

He tends to have a bad attitude, although he also has a sweet, caring and incredibly compassionate side that he shows to the ones he loves.

Unlike his character on the show, he has been in only one steady relationship with his wife Keisha Chambers since 1993, who he has 5 children with!

Sara Ramirez & Ryan DeBolt

Sara Ramirez plays the well-loved Callie Torres and she first made her appearance in Grey’s Anatomy as an orthopedic resident in the second season.

In the show, she was married to the late George O’Malley until she found out that he cheated on her with Izzie. Poor Callie was heartbroken and moved on to dating women.

Like many of her fellow Grey’s costars, Sara Ramirez struggled as an actress until she landed the role as Callie.

She made her acting debut in a small role in the movie You’ve Got Mail, followed by several one-episode appearances in series like Spin City and NYPD Blue.

Ramirez has been married to banker Ryan DeBolt since 2012.

Camilla Luddington & Matthew Alan

Camilla Luddington played Jo Wilson in the show and is a surgical resident who first joined Grey Sloan Memorial Hospital during the 9th season.

Jo had been through a lot, including being abandoned by her mother when she was a newborn and an abusive relationship with her husband, who she ran away from.

The British beauty, Camilla Luddington, got her first recurring role as Lizzie in Californication, followed by Claudette in several episodes of True Blood. She also appeared as Kate Middleton in Lifetime’s movie William & Kate.

She is currently dating 13 Reasons Why actor Matthew Alan, who also recently guest starred in an episode of Grey’s.

The couple welcomed their first child, a baby girl named Hayden, in April this year. What a beautiful couple!

Jessica Capshaw & Christopher Gavigan

Jessica Capshaw played Arizona Robbins and entered Seattle Grace during the 5th season, as a surgical fellow for the pediatric surgery department.

She and Callie started dating and eventually got married and have a daughter together named Sofia. They had a pretty rocky marriage, especially after Callie decided to amputate her wife’s leg after she was in a plane crash even though she promised not to. Yep that outta do it!

You might remember Jessica from films like Minority Report, where she played alongside Tom Cruise- however, her role on Grey’s is still her biggest and longest-lasting on-screen role that she’s ever had.

Jessica was born to perform with an actress as a mother, Kate Capshaw, and none other then Steven Spielberg as her stepfather!

She has been married to Christiopher Gavigan since 2004, with whom she has 4 children.

Kevin McKidd and Arielle Goldrath

Scottish actor Kevin McKidd played Owen Hunt in Grey’s and is the hospital’s current Head of Trauma- he came into the show during it’s fifth season.

Owen and Cristina had a pretty hot and heavy on and off relationship until they finally ended things due to their different views on having children. He is one of the hospital’s most talented surgeons, although he is known for his sometimes unorthodox methods.

Before playing Owen, Kevin McKidd starred as Tommy in the film Trainspotting and as Dan Vasser in the NBC series Journeyman!

He is the father of two children, who he has with his ex-wife Jane Parker.

However, in March this year, he married private chef Arielle Goldrath and they’re currently expecting their first child together!

Sarah Drew & Peter Lanfer

Sarah Drew played April Kepner in the show and is an attending trauma surgeon at the hospital, joining during the 6th season.

April is portrayed as a religious Christian, and often prays for her patients each time before they start surgery. April is a dedicated worker and doesn’t have much of a social life outside of work and church.

Sarah Drew landed a role as Hannah Rogers in the WB series Everwood before eventually making her big break on Grey’s.

Similar to her character on the show, she is a dedicated Christian and is the daughter and sister of a pastor.

She has been married to Peter Lanfer since 2002, with whom she has two children.

Caterina Scorsone & Rob Giles

Caterina Scorsone plays Amelia Shepherd in the show and is Derek’s youngest sister. She decided to follow in the footsteps of her big brother and became a neurosurgeon.

Later on in Grey’s, she bagan an on-off relationship with Owen and she eventually proposed to him in season 12. However, feeling like they rushed into the marriage, Amelia leaves him.

Caterina Scorsone appeared in the series Goosebumps and Power Play during the late ’90s before landing her role on Grey’s Anatomy.

She has been married to actor/musician Rob Giles since 2009.

The couple now have two children together!

T.R Knight & Patrick Leahy

T.R Knight played George O’Malley in the show and was the lovable, good-hearted surgical resident at Seattle Grace Hospital who started off as an intern in the first season.

He was best friends/lovers with Izzie and later on married Callie Torres, which ended in divorce due to his affair with Izzie and he played out one of the most emotional, heart-wrenching, heroic scenes ever in Grey’s. (we won’t spoil it for you- but we promise it’s worth a watch!)

In real life, T.R Knight is married to ballet dancer and writer Patrick Leahy.

They tied the knot in October 2013.

Katherine Heigl & Josh Kelley

Katherine Heigl played Izzie Stevens and she was one of the original surgical interns from the first season. She’s a fan favorite and her relationship with a dying patient, Denny Duquette Jr. was the highlight of the second season.

How could we ever forget Izzie crying at Denny’s bed side in her pretty pink evening gown?

When Katherine Heigl left the series after 5 years, her many fans were devastated. Grey’s made Katherine into a huge star, and she was the lead in several films such as 27 Dresses, Knocked Up and The Ugly Truth while still playing the role of Izzie.

According to the actress, she wanted to take a break in order to focus on having children and building a home with her husband Josh Kelley, who she married in 2007.

The couple now have three children together.

Chyler Leigh & Nathan West

Playing Lexie Grey in the show, Chyler Leigh is Meredith’s sister who started her internship in the 3rd season.

She had some of the most interesting and dramatic relationships, including one with George, followed by Alex and then Mark and was one of the passengers on the plane that crashed with Meredith, Cristina, Arizona, Mark and Derek on board. We’re still devastated!

Chyler Leigh had several roles in TV shows and movies before joining the cast of Grey’s, but she was best known as the lead Janey Briggs in Not Another Teen Movie.

Chyler left Grey’s in 2012 in a shocking exit, in order to spend some more time with her husband Nathan West.

They have three adorable children together.

James Pickens Jr. & Gina Taylor-Pickens

James Pickens played Dr Richard Webber in the show and played a surgical attending specializing in general surgery, and was the former Chief of Surgery, at Grey Sloan Memorial Hospital.

In addition to appearing in Grey’s Anatomy, Richard has also appeared in the Private Practice episode “In Which We Meet Addison, A Nice Girl From Somewhere Else” and “Ex-Life“.

He married his wife Gina Taylor-Pickens in 1984 and they are still happily married.

They have two children together- Carl and Gavyn.

Jesse Williams & Aryn Drake-Lee

Jackson Avery, portrayed by Jesse Williams was the Head of Plastic Surgery and attending ENT at Grey Sloan Memorial Hospital and was one of the staff members who joined from Mercy West Medical Center after the merger.

He was also a member of the board and the De Facto board chairman. Jackson was married to April Kepner in the show with whom he had a daughter with and a deceased son.

In real life Jesse Williams is not only an actor, but also a director, teacher and activist. He has appearred in many films, including The Butler, The Cabin In The Woods, Brooklyn’s Finest and The Sisterhood Of The Travelling Pants 2.

In September 2012, Williams married longtime girlfriend Aryn Drake-Lee. They have two children, Sadie and Maceo, together.

However, in April 2017, it was reported that Williams had filed for divorce and they are currently going through the details of the settlement. What a shame!

We hope you’ve enjoyed reading through this list of Grey’s Anatomy Real Life Partner’s! Who is your favourite character from the show? Let us know in the comments and feel free to share this with friends!